FGF1-FGFR1 axis promotes tongue squamous cell carcinoma (TSCC) metastasis through epithelial-mesenchymal transition (EMT)
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- 作者：Jiuyang Jiaoa ; b ; 1 ; Xiaopeng Zhaoa ; b ; 1 ; Yancan Lianga ; b ; Dongxiao Tanga ; b ; Chaobin Pana ; b ; zsupcb@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：FGF1&ndash ; FGFR1 axis ; Tongue squamous cell carcinoma ; Epithelial mesenchymal-transition ; Tumor metastasis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：23 October 2015
- 年：2015
- 卷：466
- 期：3
- 页码：327-332
- 全文大小：1085 K
文摘
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Overexpression of FGFR1 in TSCC was related to poor differentiation and metastasis.
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The expression of FGFR1 enhanced the metastatic capability of TSCC cells.
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The expression of FGFR1 prevented the EMT phenotype in TSCC cells in vitro.
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FGF1–FGFR1 axis promotes the TSCC metastasis through the EMT pathway.