Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas: Review of the literature
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- 作者：Camelia Nami Sabera ; 1 ; Christian Grø ; nhø ; j Larsena ; 1 ; c.gronhoj@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Tina Dalianisa ; b ; Christian von Buchwalda
- 关键词：APC ; antigen presenting cell ; BOTSCC ; base of tongue squamous cell carcinoma ; CD3 ; CD3+ T cell ; CD4 ; CD4+ T cell ; CD8 ; CD8+ T cells ; CSC ; cancer stem cell ; DFS ; disease-free survival ; HLA ; human leukocyte antigen ; HPV ; human papilloma virus ; N ; number of studies ; n ; number of patients ; OPSCC ; oropharyngeal squamous cell carcinoma ; p16+ ; p16 overexpression ; PB ; peripheral blood ; PRISMA ; Preferred Reporting Items for Systematic reviews and Meta-Analyses ; TNM ; tumor node metastasis ; TSCC ; tonsillar
- 刊名：Oral Oncology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：8-13
- 全文大小：382 K
文摘
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First review on immunological features of HPV-associated oropharyngeal tumors.
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Patient outcome is associated to a high number of CD8, a low CD4/CD8 ratio and CD98 positive cells, and possibly absence of HLA1.
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CD4 and HLA2 are found insignificant in relation to patient outcome.