Postoperative cognitive dysfunction and neuroinflammation; Cardiac surgery and abdominal surgery are not the same
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- 作者：Iris B. Hovensa ; b ; I.B.Hovens@rug.nl" class="auth_mail" title="E-mail the corresponding author ; Barbara L. van Leeuwenb ; Massimo A. Marianic ; Aletta D. Kraneveldd ; Regien G. Schoemakera ; e
- 关键词：Postoperative cognitive dysfunction ; Surgery ; Cardiac ; Abdominal ; Behavior ; Cognition ; Neuroinflammation ; Neutrophil gelatinase-associated lipocalin ; Brain-derived neurotrophic factor ; Neurogenesis
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：178-193
- 全文大小：2165 K
文摘
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Mechanisms underlying increased risk for POCD after cardiac surgery are studied.
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Brain and behavior in rat models for abdominal and cardiac surgery are compared.
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Abdominal surgery affects spatial memory and hippocampal neuronal functioning.
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Cognitive dysfunction is more generalized after cardiac surgery.
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Cardiac surgery causes a more general change in inflammation and neuronal function.