Clinical impact of myocardial mTORC1 activation in nonischemic dilated cardiomyopathy
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- 作者：Toshiyuki Yanoa ; Shinya Shimoshigea ; Takayuki Mikia ; Masaya Tannoa ; Atsushi Mochizukia ; Takefumi Fujitoa ; Satoshi Yudaa ; b ; Atsuko Muranakaa ; Makoto Ogasawaraa ; Akiyoshi Hashimotoa ; c ; Kazufumi Tsuchihashia ; c ; Tetsuji Miuraa ; miura@sapmed.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endomyocardial biopsy ; mTOR ; Ribosomal protein S6 ; Heart failure ; Angiotensin ; Dilated cardiomyopathy
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：6-9
- 全文大小：416 K
文摘
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The change and role of mTORC1 in human cardiomyopathy is unknown.
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Myocardial mTORC1 activity was increased in non-ischemic dilated cardiomyopathy (NICM).
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The mTORC1 activity was correlated with extent of myocardial fibrosis.
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The mTORC1 activity was higher in NICM patients who later developed cardiac events.