Randomized Comparison of Allogeneic Versus Autologous Mesenchymal Stem Cells for Nonischemic Dilated Cardiomyopathy: POSEIDON-DCM Trial

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• 作者：Joshua M. Hare ; MD^a ; ^b ; ^{JHare@med.miami.edu} ; Darcy L. DiFede ; RN ; BSN^a ; Angela C. Rieger ; MD ; MSc^a ; Victoria Florea ; MD^a ; Ana M. Landin ; PhD^a ; Jill El-Khorazaty ; MSc^c ; Aisha Khan ; MSc ; MBA^a ; Muzammil Mushtaq ; MD^b ; Maureen H. Lowery ; MD^b ; John J. Byrnes ; MD^b ; Robert C. Hendel ; MD^b ; Mauricio G. Cohen ; MD^b ; Carlos E. Alfonso ; MD^b ; Krystalenia Valasaki ; MSc^a ; Marietsy V. Pujol ; MBA^a ; Samuel Golpanian ; MD^d ; Eduard Ghersin ; MD^e ; Joel E. Fishman ; MD ; PhD^e ; Pradip Pattany ; PhD^e ; Samirah A. Gomes ; MD ; PhD^a ; Cindy Delgado ; MA^a ; Roberto Miki ; MD^b ; Fouad Abuzeid ; MD^a ; Mayra Vidro-Casiano ; MPH^a ; Courtney Premer ; BSc^a ; Audrey Medina ; BSc^a ; Valeria Porras ; BSc^a ; Konstantinos E. Hatzistergos ; PhD^a ; Erica Anderson ; MSc^c ; Adam Mendizabal ; PhD^c ; Raul Mitrani ; MD^b ; Alan W. Heldman ; MD^b
• 关键词：endothelial function ; heart failure ; idiopathic dilated cardiomyopathy ; immune biomarker ; stem cell therapy
• 刊名：Journal of the American College of Cardiology
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：69
• 期：5
• 页码：526-537
• 全文大小：1253 K
• 卷排序：69

文摘

Although human mesenchymal stem cells (hMSCs) have been tested in ischemic cardiomyopathy, few studies exist in chronic nonischemic dilated cardiomyopathy (NIDCM).ObjectivesThe authors conducted a randomized comparison of safety and efficacy of autologous (auto) versus allogeneic (allo) bone marrow-derived hMSCs in NIDCM.MethodsThirty-seven patients were randomized to either allo- or auto-hMSCs in a 1:1 ratio. Patients were recruited between December 2011 and July 2015 at the University of Miami Hospital. Patients received hMSCs (100 million) by transendocardial stem cell injection in 10 left ventricular sites. Treated patients were evaluated at baseline, 30 days, and 3-, 6-, and 12-months for safety (serious adverse events [SAE]), and efficacy endpoints: ejection fraction, Minnesota Living with Heart Failure Questionnaire, 6-min walk test, major adverse cardiac events, and immune biomarkers.ResultsThere were no 30-day treatment-emergent SAEs. Twelve-month SAE incidence was 28.2% with allo-hMSCs versus 63.5% with auto-hMSCs (p = 0.1004 for the comparison). One allo-hMSC patient developed an elevated (>80) donor-specific calculated panel reactive antibody level. The ejection fraction increased in allo-hMSC patients by 8.0 percentage points (p = 0.004) compared with 5.4 with auto-hMSCs (p = 0.116; allo vs. auto p = 0.4887). The 6-min walk test increased with allo-hMSCs by 37.0 m (p = 0.04), but not auto-hMSCs at 7.3 m (p = 0.71; auto vs. allo p = 0.0168). MLHFQ score decreased in allo-hMSC (p = 0.0022) and auto-hMSC patients (p = 0.463; auto vs. allo p = 0.172). The major adverse cardiac event rate was lower, too, in the allo group (p = 0.0186 vs. auto). Tumor necrosis factor-α decreased (p = 0.0001 for each), to a greater extent with allo-hMSCs versus auto-hMSCs at 6 months (p = 0.05).ConclusionsThese findings demonstrated safety and clinically meaningful efficacy of allo-hMSC versus auto-hMSC in NIDCM patients. Pivotal trials of allo-hMSCs are warranted based on these results. (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis in Dilated Cardiomyopathy [PoseidonDCM]; NCT01392625)