C-reactive protein is related to future cognitive impairment and decline in elderly individuals with cardiovascular disease

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• 作者：Galit Weinstein^a ; ^{galitwai@bu.edu} ; ^{galitwai@live.com} ; Miriam Lutski^b ; Uri Goldbourt^b ; David Tanne^b ; ^c
• 关键词：C-reactive protein ; Inflammation ; Cognition ; Cognitive decline ; Cardiovascular disease ; Elderly
• 刊名：Archives of Gerontology and Geriatrics
• 出版年：2017
• 出版时间：March-April 2017
• 年：2017
• 卷：69
• 期：Complete
• 页码：31-37
• 全文大小：485 K
• 卷排序：69

文摘

We explored the association between inflammation and future cognition in individuals with a history of cardiovascular disease. Increased plasma CRP levels were associated with poorer cognitive performance overall and in executive function and attention domains. A greater decline in cognition was observed in participants with high vs. low CRP. These associations were independent of vascular risk factors and markers of cerebrovascular disease.