Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance
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- 作者：Pedro Cisternasa ; Paulina Salazara ; Felipe G. Serranoa ; Carla Montecinos-Olivaa ; Sebastiá ; n B. Arredondob ; Lorena Varela-Nallarb ; Salesa Barjac ; Carlos P. Vioa ; Fernando Gomez-Pinillad ; Nibaldo C. Inestrosaa ; e ; f ; g ; ninestrosa@bio.puc.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's disease ; ACSF ; artificial cerebro-spinal fluid ; CBF ; cerebral blood flow ; fEPSP ; field excitatory postsynaptic potential ; GCL ; granule cell layer ; GLUTs ; glucose transporters ; 4-HNE ; 4-hydroxynonenal ; LTP ; long-term potentiation ; LTD ; long-term depression ; MetS ; Metabolic syndrome ; MWM ; Morris Water Maze ; PTX ; picrotoxin ; PSDs ; postsynaptic densities ; SGZ ; subgranular zone ; T2DM type II diabetes mellitus
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：1852
- 期：11
- 页码：2379-2390
- 全文大小：1671 K
文摘
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Metabolic syndrome (MetS) decreases hippocampal-dependent cognitive performance.
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MetS leads decreased hippocampal excitability and a failure to induce LTP and LTD.
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MetS leads to a reduction in hippocampal neurogenesis.
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The remission of MetS reversed cognitive and neuronal plasticity dysfunctions.
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The results provide evidence to elucidate how MetS impacts the brain disorders.