Central and peripheral neurotoxicity induced by the Jack Bean Urease (JBU) in Nauphoeta cinerea cockroaches
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- 作者：Thiago Carrazonia ; b ; c ; Marines de Avila Heberleb ; Ana Paula Artusi Perinb ; Ana Paula Zanattab ; Polyana Veloso Rodriguesb ; Fabiola Duarte Machado dos Santosb ; Carlos Gabriel Moreira de Almeidab ; c ; Ricardo Vaz Bredac ; Douglas Silva dos Santosb ; c ; d ; Paulo Marcos Pintob ; c ; Jaderson Costa da Costac ; Celia Regina Carlinia ; c ; 1 ; celia.carlini@pucrs.br" class="auth_mail" title="E-mail the corresponding author ; celia.carlini@pq.cnpq.br" class="auth_mail" title="E-mail the corresponding author ; Chá ; riston André ; Dal Belob ; c ; d ; charistonbelo@unipampa.edu.br" class="auth_mail" title="E-mail the corresponding author ; charistondb@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：JBU ; Jack Bean Urease ; ACh ; acetylcholine ; CNTX ; canatoxin ; AChE ; acetylcholinesterase ; SNCAP ; spontaneous neural compound action potentials ; DTNB ; (5 ; 5&prime ; dithiobis-(2-nitrobenzoic acid) ; TNB ; thionitrobenzoic acid ; GABA ; gama-aminobutiric acid ; GLU ; glutamate ; EPSPs ; excitatory postsynaptic potentials
- 刊名：Toxicology
- 出版年：2016
- 出版时间：10 August 2016
- 年：2016
- 卷：368-369
- 期：Complete
- 页码：162-171
- 全文大小：954 K
文摘
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Jack Bean Urease (JBU) alters behavior and physiology in Nauphoeta cinerea.
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JBU induced a positive cardiac chronotropic effect in N. cinerea.
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The cardiac effects of JBU rely on the insect cholinergic system.
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JBU increased leg but not antennae grooming by an octopaminergic route.
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JBU induces in vivo irreversible blockade of the coxal-adutor muscle in cockroaches.