Prevalence of neuropathy in type 2 diabetic patients and its association with other diabetes complications: The Verona Diabetic Foot Screening Program

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• 作者：Laura Salvotelli ; ^{laura.salvotelli@univr.it" class="auth_mail" title="E-mail the corresponding author} ; Vincenzo Stoico ; Fabrizia Perrone ; Vittorio Cacciatori ; Carlo Negri ; Corinna Brangani ; Isabella Pichiri ; Giovanni Targher ; Enzo Bonora ; Giacomo Zoppini
• 关键词：Type 2 diabetes mellitus ; Somatic neuropathy ; BMI ; HbA1c ; Complications
• 刊名：Journal of Diabetes and its Complications
• 出版年：2015
• 出版时间：November-December 2015
• 年：2015
• 卷：29
• 期：8
• 页码：1066-1070
• 全文大小：234 K

文摘

Somatic neuropathy is a chronic complication of diabetes. The purpose of our study was to determine prevalence and clinical variables associated with somatic neuropathy applying a simple screening method.

Methods

All outpatients with type 2 diabetes attending our diabetic clinic were offered to participate into a diabetic foot screening program, in the period January 2004–December 2012. A total of 3,591 diabetic patients (55.5% men, age 68 ± 10 years) underwent detection of somatic neuropathy using the Michigan Neuropathy Screening Instrument in its parts of symptoms (administering a questionnaire) and clinical assessment slightly modified (evaluating foot inspection, vibration sensation by biothesiometer, ankle reflexes).

Results

The prevalence of somatic neuropathy was 2.2% in men and 5.5% in women (p < 0.001) when assessed by symptom questionnaire, whereas it was 30.5% in men and 30.8% (p = NS) in women when identified by clinical assessment. In subjects with somatic neuropathy macro- and microvascular complications of diabetes were significantly more common. In multivariate logistic regression analyses BMI, HbA1c and ankle/brachial index independently predicted the presence of neuropathy.

Conclusion

The prevalence of somatic neuropathy in type 2 diabetes is nearly 30% when searched with clinical examination. Poor metabolic control, excess body weight and peripheral arteriopathy are independent markers of somatic neuropathy.