Nutritional factors, physical activity, and breast cancer by hormonal receptor status

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• 作者：Valentina Rosato ; Paola Bertuccio ; Cristina Bosetti ; Eva Negri ; Valeria Edefonti ; Monica Ferraroni ; Adriano Decarli ; Renato Talamini ; Luigino Dal Maso ; Fabio Falcini ; Maurizio Montella ; Silvia Franceschi ; Carlo La Vecchia
• 关键词：Breast cancer ; Case&ndash ; control study ; Hormonal receptor status ; Nutritional factors ; Physical activity
• 刊名：The Breast
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：22
• 期：5
• 页码：887-893
• 全文大小：238 K

文摘

Purpose

To investigate the association between food and nutrient intake, occupational and leisure-time physical activity, and body mass index and breast cancer risk by estrogen receptor (ER) and progesterone receptor (PR) status.

Methods

We analyzed data from a hospital-based case-control study conducted between 1991 and 1994 in Italy, including 1075 women with incident breast cancer and 1477 controls.

Results

The associations with breast cancer risk were similar according to ER status for all risk factors considered. In particular, significant reduced risk of ER? and ER+ breast cancers were observed for raw vegetables (multivariate odds ratio, OR, for high vs low consumption: 0.6 and 0.7, respectively) and for polyunsaturated fats (OR: 0.6 and 0.7, respectively). No significant heterogeneous risk estimates were observed for combinations of ER and PR status.

Conclusions

Our study does not suggest major differences risk for various dietary and lifestyle factors according to ER and PR breast cancer subtypes.