Risk Factors for Thrombosis Development in Mexican Patients

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• 作者：Cé ; sar Zavala-Herná ; ndez¹ ; Edgar Herná ; ndez-Zamora² ; ^{edgarhz1969@yahoo.com.mx" class="auth_mail" title="E-mail the corresponding author} ; Carlos Martí ; nez-Murillo³ ; Abraham Majluf-Cruz⁴ ; Jorge Vela-Ojeda⁵ ; ⁶ ; Jaime Garcí ; a-Chá ; vez⁶ ; Elba Reyes-Maldonado⁵ ; ^{elbareyesm@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Annals of Vascular Surgery
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：29
• 期：8
• 页码：1625-1632
• 全文大小：356 K

文摘

To identify inherited factors: Protein C (PC), protein S (PS), antithrombin (AT), plasminogen (Plg), the activated PC resistance (APCR), prothrombin (PT) mutation G20210 A (PTG20210 A) and methylenetetrahydrofolate reductase C677 T polymorphism (MTHFR C677 T), as well as acquired-risk factors such as: diabetes mellitus, surgeries, smoking, obesity, hypertension, trauma, alcoholism, family history; and their association, in Mexican patients with diagnostic of thrombophilia.

Methods

Overall, 200 patients diagnosed with thrombophilia and 100 healthy controls. Commercial kits were used for the coagulometric tests and polymerase chain reaction, restriction fragment length polymorphism for molecular alterations.

Results

Alterations were found with an estimated prevalence to PC 0.65%, AT 2.04% and Plg 2.5%, APCR 2%, PT 20210 2%, and MTHFR 65%. The C677 T polymorphism of the MTHFR did not associate with acquired-risk factors so we can suppose that it is an independent risk factor. For the patients that only presented acquired-risk factors (21 of 200), the association smoking–alcoholism showed to be the cause of thrombosis with high risk. The following were also associated: smoking with AT, PC, and alcoholism; obesity with Plg; smoking with alcoholism, and PS deficiency.

Conclusions

Risk factors for both primary and secondary and their association were present as a cause of thrombosis in the patients studied, and the possibility to suffer a recurrent thrombosis.