Optimal Generation of Tissue-Resident but Not Circulating Memory T Cells during Viral Infection Requires Crosspriming by DNGR-1+ Dendritic Cells
详细信息 查看全文
- 作者：Salvador Iborra1 ; siborra@cnic.es" class="auth_mail" title="E-mail the corresponding author ; Marí ; a Martí ; nez-Ló ; pez1 ; Sofí ; a C. Khouili1 ; Michel Enamorado1 ; Francisco J. Cueto1 ; 2 ; Ruth Conde-Garrosa1 ; Carlos del Fresno1 ; David Sancho1 ; 3 ; dsancho@cnic.es" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：45
- 期：4
- 页码：847-860
- 全文大小：4144 K
文摘
- •
Distinct priming requirements of Trm versus circulating memory in viral infection
- •
Genetic or antibody blockade of crosspriming selectively impairs Trm generation
- •
Unique signals from DNGR-1+ DC induce T-bet and retain naive T cells for LN priming
- •
Protective mucosal immunity depends on optimal Trm induction by DNGR-1+ DC