Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain

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• 作者：Juan Ledesma^a ; ^{jledesmam@isciii.es"" rel=""nofollow} ; Diego Vicente^b ; ¹ ; Francisco Pozo^a ; Gustavo Cilla^b ; Sonia P&#xe9 ; rez Castro^c ; Jonathan Su&#xe1 ; rez Fern&#xe1 ; ndez^c ; Mercedes P&#xe9 ; rez Ruiz^d ; Jos&#xe9 ; Mar&#xed ; a Navarro^d ; Juan Carlos Gal&#xe1 ; n^e ; Mirian Fern&#xe1 ; ndez^f ; Jordi Reina^g ; Amparo Larrauri^h ; Mar&#xed ; a Teresa Cuevas^a ; Inmaculada Casas^a ; Pilar P&#xe9 ; rez Breñ ; a^a ; the Spanish Influenza Surveillance System (SISS)^j
• 关键词：Influenza ; Neuraminidase ; H275Y mutation ; Oseltamivir-resistance
• 刊名：Journal of Clinical Virology
• 出版年：2011
• 出版时间：July 2011
• 年：2011
• 卷：51
• 期：3
• 页码：205-208
• 全文大小：169 K

文摘

Background

Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir.

Objectives

To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation.

Study design

A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010.

Results

H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93 % ) who previously received treatment with oseltamivir. Six of these patients were immunocompromised.

Conclusion

In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country.