- 作者：Ana Maria Baptista Menezes ; Adriana Mui帽o ; Maria Victorina L贸pez-Varela ; Gonzalo Valdivia ; Carmen Lisboa ; Jos茅 Roberto Jardim ; Maria Montes de Oca ; Carlos T谩lamo ; Fern ; o C茅sar Wehrmeister ; Rogelio Perez-Padilla ; Equipo del estudio Platino
- 关键词：Chronic obstructive pulmonary disease ; Longitudinal studies ; Latin America
- 刊名：Archivos de Bronconeumología (English Edition)
- 出版年：January, 2014
- 年：2014
- 卷：50
- 期：1
- 页码：10-17
- 全文大小：566 K
Background
The PLATINO baseline study, conducted from 2003 to 2005 in five Latin American cities (S茫o Paulo, Mexico City, Montevideo, Santiago, Caracas), showed a high prevalence of chronic obstructive pulmonary disease (COPD).Methods/design
A follow-up study was conducted in three out of the five centers (Montevideo, Santiago, and S茫o Paulo) after a period of 5, 6 and 9 years, respectively, aimed at verifying the stability of the COPD diagnosis over time, the evolution of the disease in terms of survival, morbidity and respiratory function, and the analyses of inflammatory and genetic biomarkers in the blood. Some questions were added to the original questionnaire and death certificates were obtained from the national official registries.
Results
The fieldwork has been concluded in the three centers. From the original samples in the PLATINO study phase i, we were able to locate and interview 85.6% of patients in Montevideo, 84.7% in Santiago and 77.7% in S茫o Paulo. Individuals who could not be located had higher education levels in Brazil, and were more likely to be current smokers in Santiago and S茫o Paulo than in Montevideo. The overall quality of spirometries was 鈮?0% according to American Thoracic Society criteria. The number of deaths was 71 (Montevideo), 95 (Santiago) and 135 (S茫o Paulo), with death certificates obtained from the national mortality registries for 76.1%, 88.3% and 91.8% of cases in Montevideo, Santiago and S茫o Paulo, respectively.
Conclusions
This study shows that it is possible to perform population-based longitudinal studies in Latin American with high follow-up rates and high-quality spirometry data. The adequacy of national mortality registries varies among centers in Latin America.