Comorbidities and Health Status in Individuals With and Without COPD in Five Latin American Cities: The PLATINO Study

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• 作者：Maria Victorina L贸pez Varela ; Mar铆a Montes de Oca ; Ronald Halbert ; Adriana Mui帽o ; Carlos T谩lamo ; Rogelio P茅rez-Padilla ; Jos茅 Roberto B. Jardim ; Gonzalo Valdivia ; Julio Pertuz茅 ; Ana Mar铆a B. Menezes ; on behalf of the PLATINO Team
• 关键词：Epidemiology ; Comorbidities ; General health status ; Chronic obstructive pulmonary disease
• 刊名：Archivos de Bronconeumología (English Edition)
• 出版年：November, 2013
• 年：2013
• 卷：49
• 期：11
• 页码：468-474
• 全文大小：765 K

文摘

Introduction

Comorbidities are common in patients with chronic obstructive pulmonary disease (COPD), and have a significant impact on health status and prognosis. The PLATINO study provides data on self-reported comorbidities and perceived health status in COPD subjects.

Methods

PLATINO is a population-based study on COPD prevalence in five Latin American cities. COPD diagnosis was defined by GOLD criteria (FEV₁/FVC<.70 post-bronchodilator). Information was collected on the following comorbidities: heart disease, hypertension, diabetes, cerebrovascular disease, peptic ulcer and asthma. Health status was evaluated using the SF-12 questionnaire, derived from the question: 鈥淚n general, would you say your health is excellent, very good, good, fair or poor?鈥?A simple comorbidity score was calculated by adding the total number of comorbid conditions.

Results

Of a total population of 5314 individuals, 759 had COPD. Reported comorbidities by decreasing frequency were: any cardiovascular disease, hypertension, peptic ulcer, heart disease, diabetes, cerebrovascular disease, asthma and lung cancer. COPD patients had a higher comorbidity score and prevalence of lung cancer (P<.0001) and asthma (P<.0001), as well as a higher tendency to have hypertension (P=.0652) and cerebrovascular disease (P=.0750). Factors associated with comorbidities were age, body mass index (BMI) and female gender. The number of comorbidities increased as the health status deteriorated.

Conclusions

In the PLATINO population-based study, COPD individuals had an increased number of comorbidities. Age, female gender and higher BMI were the factors associated with comorbidity in these patients. Comorbid conditions were associated with impaired health status, independently of the COPD status.