Retroactivity effects dependency on the transcription factors binding mechanisms
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- 作者：Libertad Pantoja-Herná ; ndeza ; b ; lpantoja@lcg.unam.mx" class="auth_mail" title="E-mail the corresponding author ; Elena Á ; lvarez-Buyllaa ; b ; Carlos F. Aguilar-Ibá ; ñ ; ezc ; Adriana Garay-Arroyoa ; Alberto Soria-Ló ; pezd ; Juan Carlos Martí ; nez-Garcí ; ad ; juancarlos_martinez-garcia@conciliencia.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：FFTF ; Free functional transcription factor ; BS ; Binding site ; TF ; Transcription factor ; TFBP ; Transcription factor binding process ; BM ; Binding mechanism ; SMB ; Simple monomer binding ; DB ; Dimer Binding ; CSB ; Cooperative sequential binding ; CSB_D ; Cooperative sequential binding along with dimerization
- 刊名：Journal of Theoretical Biology
- 出版年：2016
- 出版时间：7 December 2016
- 年：2016
- 卷：410
- 期：Complete
- 页码：77-106
- 全文大小：12776 K
文摘
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Our aim is to find out how binding mechanisms account for differential retroactivity effects.
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We examined changes in the FFTF and its variability in presence of loads.
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We modeled the mechanisms assuming all the systems reach the same steady state. Simple monomer binding was the most resistant mechanism to retroactivity.
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DB is the mechanism where loads changed the most the SS and FFTF number of molecules.