Systems biology of host-mycobiota interactions: Dissecting Dectin-1 and Dectin-2 signalling in immune cells with DC-ATLAS

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• 作者：Lisa Rizzetto ; Carlotta De Filippo ; Damariz Rivero ; Samantha Riccadonna ; Luca Beltrame ; Duccio Cavalieri
• 关键词：BCML ; Biological Connection Markup Language ; BMDCs ; bone marrow dendritic cells ; BMM ; bone marrow derived macrophages ; CLR ; C-type lectin like receptor ; DCs ; dendritic cells ; moDCs ; monocyte derived dendritic cells ; IL ; interleukin ; PRR ; pathogen recognit
• 刊名：Immunobiology
• 出版年：2013
• 出版时间：November, 2013
• 年：2013
• 卷：218
• 期：11
• 页码：1428-1437
• 全文大小：1732 K

文摘

Modelling the networks sustaining the fruitful coexistence between fungi and their mammalian hosts is becoming increasingly important to control emerging fungal pathogens.

The C-type lectins Dectin-1 and Dectin-2 are involved in host defense mechanisms against fungal infection driving inflammatory and adaptive immune responses and complement in containing fungal burdens. Recognizing carbohydrate structures in pathogens, their engagement induces maturation of dendritic cells (DCs) into potent immuno-stimulatory cells endowed with the capacity to efficiently prime T cells. Owing to these properties, Dectin-1 and Dectin-2 agonists are currently under investigation as promising adjuvants in vaccination procedures for the treatment of fungal infection. Thus, a detailed understanding of events¡¯ cascade specifically triggered in DCs upon engagement is of great interest in translational research. Here, we summarize the current knowledge on Dectin-1 and Dectin-2 signalling in DCs highlighting similarities and differences. Detailed maps are annotated, using the Biological Connection Markup Language (BCML) data model, and stored in DC-ATLAS, a versatile resource for the interpretation of high-throughput data generated perturbing the signalling network of DCs.