SRB1 as a new redox target of cigarette smoke in human sebocytes

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• 作者：Ilaria Crivellari^a ; ^b ; Claudia Sticozzi^a ; Giuseppe Belmonte^a ; Ximena M. Muresan^a ; Franco Cervellati^a ; Alessandra Pecorelli^a ; Carlotta Cavicchio^a ; Emanuela Maioli^c ; Christos C. Zouboulis^d ; Mascia Benedusi^a ; Carlo Cervellati^b ; Giuseppe Valacchi^a ; ^e ; ^{giuseppe.valacchi@unife.it} ; ^{gvalacc@ncsu.edu}
• 关键词：Hydroxynonenal ; Lipids ; Smoke ; Cutaneous tissue
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：47-56
• 全文大小：1452 K
• 卷排序：102

文摘

Sebocytes are involved in maintaining skin functions. Skin is the first barrier against outdoor insults. Cigarette smoke (CS) affects skin homeostasis. CS decreases SRB1 levels compromising sebocytes cholesterol uptake. Lipids are essential to keep skin functionality.