Remote location interstitial brachytherapy with patient stabilization and subsequent transport to an outpatient center for treatment is safe and effective for the treatment of gynecologic malignancies

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• 作者：Vasu Tumati¹ ; Michael R. Folkert¹ ; ² ; Sandra Lawson¹ ; Elsa Wise¹ ; Sheila Wolcott¹ ; Debra Richardson³ ; Matthew Carlson³ ; Siobhan Kehoe³ ; Jayanthi Lea³ ; Ramzi Abdulrahman¹ ; ² ; Kevin Albuquerque¹ ; ² ; ^{kevin.albuquerque@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Interstitial brachytherapy ; Transport ; Gynecologic malignancy ; Treatment complications
• 刊名：Brachytherapy
• 出版年：2016
• 出版时间：May-June 2016
• 年：2016
• 卷：15
• 期：3
• 页码：341-346
• 全文大小：618 K

文摘

Interstitial brachytherapy is an essential component of definitive treatment for locally advanced gynecological malignancies. Although many outpatient centers are capable of delivering the radiation component of brachytherapy, they are not associated with an operative center for implant placement, limiting the ability to deliver appropriate care. In this study, we report on our experience with noncolocated implant placement and radiation delivery, and the impact of patient stabilization improvements on patient safety.

Methods and Materials

ra0015">Between 9/2010 and 11/2014, 25 patients with gynecologic malignancy underwent interstitial implantation and subsequent transport for high-dose-rate brachytherapy treatment. From 9/2010 to 10/2012, patients were transported using a standard ambulance stretcher; from 11/2012 to 11/2014, patients were placed on a patient positioning board or a WAFFLE support. Potential transport-associated toxicity was assessed, and the association between standard and augmented transport types and toxicity was analyzed.

Results

ra0020">A total of 234 transports were performed. Median cost of transport was $150 per transport. There were 14 (10 patients) potential transportation-associated toxicities, including two lacerations/local trauma, three infections, and nine ulcers. There were 6 Grade 3 toxicities, all in the standard group. There was no association between stretcher type and laceration or ulcers, but enhanced support was associated with fewer overall toxicities, Grade 3 toxicities, and infections.

Conclusions

ra0025">Noncolocated implantation and treatment is safe and facilitates optimal therapy. Toxicities potentially associated with transport are minimal and seem to be reduced by augmented stabilization. Understanding that this is a reasonable way to deliver brachytherapy may allow more stand-alone centers to deliver high-quality care for patients and improve gynecologic cancer outcomes in the United States.