A compact and multichannel optical biosensor based on a wavelength interrogated input grating coupler

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• 作者：Sonia Grego ; ^{sgrego@rti.org}  ; [Author Vitae] ; Kristin H. Gilchrist  ; [Author Vitae] ; James B. Carlson  ; [Author Vitae] ; Brian R. Stoner  ; [Author Vitae]
• 关键词：Optical waveguide ; Tunable laser ; Grating ; Multichannel sensor ; Portable biosensor
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2012
• 出版时间：3 January 2012
• 年：2012
• 卷：161
• 期：1
• 页码：721-727
• 全文大小：763 K

文摘

The design, fabrication and characterization of a compact optical biosensor based on an input grating coupler are presented. The sensor device consists of a waveguide-integrated single grating structure. The optical reader is based on the use of a largely tunable, small footprint infrared laser for wavelength interrogation of the sensor and on edge-detection of waveguided modes, resulting in a compact configuration. A multiplexing approach is illustrated and a two-output sensor system is demonstrated. The device is packaged in a microfluidic cartridge for sample handling. The volumetric sensing performance of the system is characterized and a limit of detection of 1 ¡Á 10^? RIU is reported while the surface sensing capability is demonstrated by detection of protein diluted down to 200 ng/ml.