Comparative analysis of the immunomodulatory capacities of human bone marrow- and adipose tissue-derived mesenchymal stromal cells from the same donor
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文摘

BM-MSCs and AT-MSCs induced a similar decrease in NK cell proliferation and cytokine secretion.

BM-MSCs show higher capacity than AT-MSCs to inhibit NK cell cytotoxic activity but the same susceptibility to NK cell lysis.

AT-MSCs are more potent in inhibiting DC differentiation than BM-MSCs, but both similarly reduced the ability of DCs to induce CD4+ T cell proliferation and cytokine production.

BM-MSCs and AT-MSCs induce a similar decrease in T cell proliferation and production of inflammatory cytokines after activation.

MSCs from different donors could exert different immunomodulatory potential on the same receptor.

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