NT-proBNP: A cardiac biomarker to assess prognosis in non-Hodgkin lymphoma

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• 作者：Eva Gimenop>ap>p> ; p>p>bp>p> ; p>p>cp>p> ; p>p>94015@hospitaldelmar.cat"" rel=""nofollowp> ; Miquel Gó ; mezp>dp> ; Juan Ramó ; n Gonz&#xe1 ; lezp>cp>p> ; p>p>ep>p> ; p>p>fp> ; Josep Com&#xed ; np>dp> ; Alberto Alvarez-Larr&#xe1 ; np>ap>p> ; p>p>bp> ; Blanca S&#xe1 ; nchez-Gonz&#xe1 ; lezp>ap>p> ; p>p>bp> ; Lluis Molinap>dp> ; Eva Domingo-Domenechp>gp> ; Francesc Garcia-Pallarolsp>ap> ; Carmen Pedrop>ap>p> ; p>p>bp> ; Eugenia Abellap>ap>p> ; p>p>bp> ; Carles Vilaplanap>hp> ; Silvia de Sanjos&#xe9 ; p>ip> ; Carlos Bessesp>ap>p> ; p>p>bp> ; Antonio Salarp>ap>p> ; p>p>bp>
• 关键词：Non-Hodgkin lymphoma ; NT-proBNP ; Prognostic factor
• 刊名：Leukemia Research
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：35
• 期：6
• 页码：715-720
• 全文大小：400 K

文摘

NT-proBNP provides diagnostic and prognostic information in heart syndromes but its role in cancer has not yet been established. The prognostic value of NT-proBNP was prospectively studied in 104 non-Hodgkin lymphoma (NHL) patients treated with chemotherapy. Echocardiography and NT-proBNP were determined prior to treatment. In multivariate analysis, NT-proBNP ≥ 900 pg/ml was the variable with higher risk of death (adjusted hazard ratio 11.1; 95 % CI 3.8–32.9; P < 0.001). The C statistic for NT-proBNP ≥ 900 pg/ml was significantly better than IPI score for prediction of survival. These findings suggest that NT-proBNP ≥ 900 pg/ml could be considered a useful marker for risk assessment in NHL patients treated with chemotherapy.