Relevance of carnosic acid to the treatment of several health disorders: Molecular targets and mechanisms

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• 作者：Sana Bahri^a ; ^b ; ^{bahrisana88@gmail.com} ; Saloua Jameleddine^a ; Vadim Shlyonsky^b
• 关键词：Carnosic acid ; Antioxidant ; Anti-inflammatory ; Antitumor
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：84
• 期：Complete
• 页码：569-582
• 全文大小：1086 K
• 卷排序：84

文摘

Carnosic acid is a phenolic diterperne compound found in abundance in sage and rosemary, which are both widely used in traditional medicine. Research over the past decade indicates that carnosic acid has multiple bioactive properties including antioxidant, anti-inflammatory and anticancer activities among others. This review summarizes the current in vitro and in vivo data about the efficacy of carnosic acid in the prevention or treatment of various experimental health disorders. The analysis of the literature allows an insight into the participation of numerous signaling pathways modulated by carnosic acid, into its synergistic potential and, thus, into the divergence in cellular mechanisms of action of this molecule.