Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

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• 作者：Christoph S.N. Klose¹ ; ² ; ⁸ ; ¹¹ ; Melanie Flach¹ ; ² ; ¹¹ ; Luisa Mö ; hle³ ; Leif Rogell¹ ; ² ; ⁴ ; Thomas Hoyler¹ ; ² ; Karolina Ebert¹ ; ² ; ⁸ ; Carola Fabiunke¹ ; ² ; ⁸ ; Dietmar Pfeifer⁵ ; Veronika Sexl⁶ ; Diogo Fonseca-Pereira⁷ ; Rita G. Domingues⁷ ; Henrique Veiga-Fernandes⁷ ; Sebastian J. Arnold⁸ ; ⁹ ; Meinrad Busslinger¹⁰ ; Ildiko R. Dunay³ ; Yakup Tanriver² ; ⁸ ; ¹² ; Andreas Diefenbach¹ ; ¹² ; ^{diefenbach@uni-mainz.de" class="auth_mail}
• 刊名：Cell
• 出版年：10 April, 2014
• 年：2014
• 卷：157
• 期：2
• 页码：340-356
• 全文大小：2974 K

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Summary

Innate lymphoid cells (ILCs) are a recently recognized group of lymphocytes that have important functions in protecting epithelial barriers against infections and in maintaining organ homeostasis. ILCs have been categorized into three distinct groups, transcriptional circuitry and effector functions of which strikingly resemble the various T helper cell subsets. Here, we identify a common, Id2-expressing progenitor to all interleukin 7 receptor-expressing, 鈥渉elper-like鈥?ILC lineages, the CHILP. Interestingly, the CHILP differentiated into ILC2 and ILC3 lineages, but not into conventional natural killer (cNK) cells that have been considered an ILC1 subset. Instead, the CHILP gave rise to a peculiar NKp46⁺ IL-7R伪⁺ ILC lineage that required T-bet for specification and was distinct of cNK cells聽or other ILC lineages. Such ILC1s coproduced聽high levels of IFN-纬 and TNF and protected聽against聽infections with the intracellular parasite Toxoplasma gondii. Our data significantly advance聽our understanding of ILC differentiation聽and聽presents evidence for a new ILC lineage that聽protects barrier surfaces against intracellular infections.