The use of high-dose estrogens for the treatment of breast cancer

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• 作者：Herjan J.T. Coelingh Bennink^a ; Carole Verhoeven^a ; ^{cv@pantarheibio.com} ; Alice E. Dutman^a ; Jos Thijssen^b
• 关键词：Estrogen ; Breast cancer ; Endocrine resistance ; Estrogen gap
• 刊名：Maturitas
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：11-23
• 全文大小：1130 K
• 卷排序：95

文摘

High-dose estrogens are effective for the treatment of advanced breast cancer. A previous long period of estrogen deprivation is required for high-dose estrogens to be efficacious in this regard. Apoptosis induced by estrogens is regulated via the ERα receptor. High-dose estrogens are a valuable alternative to chemotherapy in selected patients.