Phthalimido-thiazoles as building blocks and their effects on the growth and morphology of Trypanosoma cruzi
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- 作者：Paulo André ; Teixeira de Moraes Gomesa ; Arsê ; nio Rodrigues Oliveiraa ; Marcos Verí ; ssimo de Oliveira Cardosoa ; Edna de Farias Santiagoa ; Miria de Oliveira Barbosaa ; Lucianna Rabelo Pessoa de Siqueiraa ; Diogo Rodrigo Magalhã ; es Moreirab ; Tanira Matutino Bastosb ; Fá ; bio André ; Braynerc ; Milena Botelho Pereira Soaresb ; d ; Andresa Pereira de Oliveira Mendese ; Maria Carolina Accioly Brelaz de Castroe ; Valé ; ria Rego Alves Pereirae ; Ana Cristina Lima Leitea ; acllb2003@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chagas disease ; Trypanosoma cruzi ; Thiazole ; Hydrazone ; Phthalimide
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：23 March 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：46-57
- 全文大小：1663 K
文摘
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The anti-T. cruzi activity of 26 phthalimido-thiazoles were evaluated.
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Five compounds presented better trypanocidal activity than Benznidazole.
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Compound 6j was 26-fold more selective than Benznidazole.
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The structural upgrade planned present positive effects on trypanocidal activity.