Current drug therapy and pharmaceutical challenges for Chagas disease
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- 作者：José ; Bermudez1 ; a ; Carolina Davies1 ; b ; Analí ; a Simonazzia ; Juan Pablo Realc ; Santiago Palmac ; sdpalma@fcq.unc.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chagas disease ; Trypanosoma cruzi ; Trypanocidal treatment ; Benznidazol ; Nifurtimox ; New medication
- 刊名：Acta Tropica
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：156
- 期：Complete
- 页码：1-16
- 全文大小：2046 K
文摘
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Chagas disease is one of the greatest therapeutic challenges in tropical medicine.
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Different strategies are being sought to overcome Benznidazole’s toxicity.
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Parasitic persistence is the main cause of progression towards cardiomyopathy.
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New drug candidates may struggle to reach the market in the future.