Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test
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- 作者：Nils Klü ; ver
- 关键词：Zebrafish embryo ; FET ; Toxicity baseline QSAR ; Liposome-water partition coefficient ; Internal lethal concentration ; Chemical activity
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：164
- 期：Complete
- 页码：164-173
- 全文大小：1193 K
文摘
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- <p id="p0010">Common baseline toxicity QSAR for fish embryo LC50 was established.p>
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- <p id="p0015">ILC50 and La50 analysis corroborated the robustness of baseline toxicity QSAR.p>
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- <p id="p0020">Compounds with specific or reactive MOA converged towards baseline toxicity with increasing hydrophobicity.p>
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- <p id="p0025">For compounds with log Klipw < 4 the TR approach can be used to classify compounds.p>