Effect of the dibenzylbutyrolactone lignan (−)-hinokinin on doxorubicin and methyl methanesulfonate clastogenicity in V79 Chinese hamster lung fibroblasts
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- 作者：Flá ; via Aparecida Resende ; Iara Maluf Tomazella ; Lilian Cristina Barbosa ; Marina Ponce ; Ricardo Andrade Furtado ; Ana Carolina Pereira ; Jairo Kenupp Bastos ; Má ; rcio Luí ; s Andrade e Silva ; D
- 关键词：Hinokinin ; Micronucleus ; V79 cell ; Clastogenicity
- 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- 出版年：2010
- 出版时间：19 July 2010
- 年：2010
- 卷：700
- 期：1-2
- 页码：62-66
- 全文大小：200 K
文摘
The dibenzylbutyrolactone lignan (−)-hinokinin (HK) was obtained by partial synthesis from (−)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba. In view of the trypanocidal activity of HK and its potential as a lead compound for drug development, evaluation of its possible genotoxic activity is required. We have tested HK for possible genotoxicity and evaluated the compound's effect on the activity of the clastogens doxorubicin (DXR) and methyl methanesulfonate (MMS) in the micronucleus (MN) assay with Chinese hamster lung fibroblast V79 cells. HK alone did not induce MN, at concentrations up to 128 μM. In combined treatments, HK reduced the frequency of MN induced by MMS. With respect to DXR, HK exerted a protective effect at lower concentrations, but at higher concentrations it potentiated DXR clastogenicity.