Specific Factors Influence Postconcussion Symptom Duration among Youth Referred to a Sports Concussion Clinic

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• 作者：Geoffrey L. Heyer ; MD¹ ; ² ; ^{geoffrey.heyer@nationwidechildrens.org" class="auth_mail" title="E-mail the corresponding author} ; Caroline E. Schaffer ; BS³ ; Sean C. Rose ; MD¹ ; ² ; Julie A. Young ; ATC⁴ ; Kelly A. McNally ; PhD⁵ ; ⁶ ; Anastasia N. Fischer ; MD⁴
• 关键词：traumatic brain injury ; TBI ; mTBI ; pediatric ; adolescent
• 刊名：The Journal of Pediatrics
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：174
• 期：Complete
• 页码：33-38.e2
• 全文大小：436 K

文摘

To identify the clinical factors that influence the duration of postconcussion symptoms among youth referred to a sports concussion clinic.

Study design

A retrospective cohort study was conducted to evaluate several potential predictors of symptom duration via a Cox proportional hazards analyses. The individual postconcussion symptom scores were highly correlated, so these symptoms were analyzed in the statistical model as coefficients derived from principal component analyses.

Results

Among 1953 youth with concussion, 1755 (89.9%) had dates of reported symptom resolution. The remainder (10.1%) were lost to follow-up and censored. The median time to recovery was 18 days (range 1-353 days). By 30 days, 72.6% had recovered; by 60 days, 91.4% had recovered; and by 90 days, 96.8% had recovered. Several variables in a multivariate Cox model predicted postconcussion symptom duration: female sex (P < .001, hazard ratio [HR] = 1.28), continued activity participation (P = .02, HR = 1.13), loss of consciousness (P = .03, HR = 1.18), anterograde amnesia (P = .04, HR = 1.15), premorbid headaches (P = .03, HR = 1.15), symptom components from the day of concussion (emotion, P = .03, HR = 1.08), and the day of clinic evaluation (cognitive-fatigue, P < .001, HR = 1.22; cephalalgic, P < .001, HR = 1.27; emotional, P = .05, HR = 1.08; arousal-stimulation, P = .003, HR = 1.1). In univariate analyses, greater symptom scores generally predicted longer symptom durations. Worsening of symptoms from the day of concussion to the day of clinic evaluation also predicted longer recovery (P < .001, HR = 1.59).

Conclusions

Several factors help to predict protracted postconcussion symptom durations among youth referred to a sports concussion clinic.