• 作者：Yannick Simonin^a ; ^b ; ^{yannick.simonin@umontpellier.fr" class="auth_mail" title="E-mail the corresponding author} ; Fabien Loustalot^a ; Caroline Desmetz^b ; Vincent Foulongne^a ; ^c ; Orianne Constant^a ; Chantal Fournier-Wirth^a ; ^d ; Fanny Leon^a ; ^d ; Jean-Pierre Molè ; s^a ; Auré ; lien Goubaud^e ; ^f ; Jean-Marc Lemaitre^e ; ^f ; Marianne Maquart^g ; Isabelle Leparc-Goffart^g ; Laurence Briant^h ; Nicolas Nagot^a ; ^c ; Philippe Van de Perre^a ; ^c ; Sara Salinas^a ; ^{sara.salinas@inserm.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Zika virus ; Lineages ; Neural stem cells ; Astrocytes
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：161-169
• 全文大小：989 K

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ZIKV from two Asian and African strains infect differentially IPSc-derived NSCs

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African ZIKV strain displays more infectivity and anti-viral response

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African and Asian ZIKV strains infect and replicate efficiently in human astrocytes

Zika virus (ZIKV) is involved in a major epidemic in Latin America. Some neurological complications are reported following infection, in particular microcephaly and Guillain-Barré syndromes. Analyses show that one Asian and two Africans lineages exist. Although originally discovered in Africa in 1947, the actual epidemic is due to Asian ZIKV. Here, we compared the virulence of two African and Asian ZIKV strains in neural cells. We showed that in human neural stem cells, African ZIKV strain had a higher infectivity and triggered stronger cellular response. Altogether, our results highlight the need to better characterize ZIKV lineages to anticipate further epidemics.