Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists
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- 作者：Carolyn D. Dzierba ; Thais M. Sielecki ; Argyrios G. Arvanitis ; Amy Galka ; Tricia L. Johnson ; Amy G. Takvorian ; Maria Rafalski ; Padmaja Kasireddy-Polam ; Shikha Vig ; Bireshwar Dasgupta ; Ge Zhang ; Thaddeus F. Molski ; Harvey Wong ; Robert C. Zaczek ; Nicholas J. Lodge ; Andrew P. Combs ; Paul J. Gilligan ; George L. Trainor ; Joanne J. Bronson ; John E. Macor ; et al.
- 关键词：GXWKAWZLOBUGGM-UHFFFAOYSA-N
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2012
- 出版时间：1 August, 2012
- 年：2012
- 卷：22
- 期：15
- 页码：4986-4989
- 全文大小：782 K
文摘
Pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones were evaluated as corticotropin-releasing factor-1 receptor antagonists. The synthesis, SAR studies and pharmacokinetic evaluation of these analogs are described herein.