Fecal carriage of extended-spectrum and AmpC β-lactamase-producing Enterobacteriaceae in surgical patients before and after antibiotic prophylaxis
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- 作者：Lotte Jakobsena ; lottejakobsen@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Katrin G. Kuhna ; Frank Hansena ; Robert L. Skova ; Anette M. Hammeruma ; Pia J. Littauerb ; Ole Thorlacius-Ussingc ; d ; Peter H. Gebuhre ; Jenny D. Knudsenb ; 1 ; Henrik C. Schø ; nheyderd ; f ; 1
- 关键词：Beta-lactamases ; ESBL ; AmpC ; Enterobacteriaceae ; Antibiotic prophylaxis ; Surgical procedures ; Operative ; Denmark
- 刊名：Diagnostic Microbiology & Infectious Disease
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：86
- 期：3
- 页码：316-321
- 全文大小：998 K
文摘
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Two-cohort study including 750 patients to scrutinize the actual impact of prophylactic gentamicin/penicillin G or cefuroxime on ESBL/AmpC/CPE carrier status, which is poorly investigated.
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Low carriage rate of ESBL/AmpC/CPE in the two included patient cohorts prior to surgery was detected.
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No significant impact on the fecal carriage of ESBL/AmpC-producing Enterobacteriaceae by use of gentamicin/penicillin G or cefuroxime was detected 2-days post surgery.
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In one cohort, carriage was significantly associated with previous hospital admission and antimicrobial treatment, and men had a greater risk of carriage than women.