Reprint of “EXOSOME LEVELS IN HUMAN BODY FLUIDS: A TUMOR MARKER BY THEMSELVES?”

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• 作者：Francesco Cappello^a ; ^b ; Mariantonia Logozzi^c ; Claudia Campanella^a ; ^b ; Celeste Caruso Bavisotto^a ; ^b ; Antonio Marcilla^d ; ^e ; Francesca Properzi^c ; Stefano Fais^c ; ^{stefano.fais@iss.it}
• 关键词：Extracellular vesicles ; Exosomes ; Biomarkers ; Body fluids ; Early diagnosis ; Follow-up ; Prostate cancer
• 刊名：European Journal of Pharmaceutical Sciences
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：98
• 期：Complete
• 页码：64-69
• 全文大小：518 K
• 卷排序：98

文摘

Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can at once provide with several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may by themselves represent a predictive/diagnostic of tumors, discriminating cancer patients from healthy subjects. The aim of this review is to highlight these latest challenging findings to provide novel and groundbreaking ideas for successful tumor early diagnosis and follow-up.