Th1 and Th2-like Protein Balance in Human Inflammatory Radicular Cysts and Periapical Granulomas

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• 作者：Carlos Alberto de Carvalho Fraga ; MS^&lowast ; ; Lucas Rodrigues Alves ; DDS^&lowast ; ; Adriana Alkmim de Sousa ; DDS^&lowast ; ; Sabrina Ferreira de Jesus ; BS^&lowast ; ; Daniel Nogueira Vilela ; UGMS^&dagger ; ; Camila Santos Pereira ; MS^&lowast ; ; Patrí ; cia Luciana Batista Domingos ; MS^&lowast ; ; Agostinho Gonç ; alves Viana ; MS^&lowast ; ; Bruno Correia Jham ; PhD^&Dagger ; ; Alfredo Maurí ; cio Batista de Paula ; PhD^&lowast ; ; André ; Luiz Sena Guimar&atilde ; es ; PhD^&lowast ; ; ^{andreluizguimaraes@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Inflammatory radicular cysts ; periapical granulomas ; T helper 1 ; T helper 2
• 刊名：Journal of Endodontics
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：39
• 期：4
• 页码：453-455
• 全文大小：347 K

文摘

Chronic dental periapical lesions result from chronic inflammation of periapical tissues caused by continuous antigenic stimulation from infected root canals. Recent findings have suggested that T helper (Th) 1 and Th2-like cytokines are important in the pathogenesis of chronic periapical inflammatory diseases. However, the mechanisms regulating these immunoinflammatory pathways have not been fully elucidated. Thus, the aim of this study was to evaluate interleukin (IL)-4, IL-12, and interferon γ (IFN-γ) protein levels in human radicular cysts and periapical granulomas.

Methods

Archived samples of cysts (n = 52) and granulomas (n = 27) were sectioned and submitted to immunohistochemistry to evaluate the tissue expression of IL-4, IL-12, and IFN-γ. The data were analyzed using the Mann-Whitney U test (P < .05).

Results

An increased expression of IFN-γ was observed in radicular cysts. IL-4 expression was stronger in periapical granulomas than in radicular cysts. IL-12 was not detected in any of the samples.

Conclusions

Our study showed that IFN-γ protein levels are increased in radicular cysts, whereas IL-4 expression is stronger in samples of periapical granulomas. Further studies are necessary to elucidate the signaling pathways mediated by these cytokines and to facilitate the development of more effective periapical disease management strategies.