Increasing demonstration of angiogenic markers in skin neoplastic lesions

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• 作者：Carla Mendonç ; a de Almeida^a ; ¹ ; Sabina Ferreira de Jesus^a ; ¹ ; Fabiano de Oliveira Poswar^a ; ^b ; Emisael Stê ; nio Batista Gomes^a ; Carlos Alberto de Carvalho Fraga^a ; Lucyana Conceiç ; ã ; o Farias^a ; Sé ; rgio Henrique Souza Santos^c ; John David Feltenberger^d ; Alfredo Maurí ; cio Batista de Paula^a ; André ; Luiz Sena Guimarã ; es^a ; ^{andreluizguimaraes@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Basal cell carcinoma ; Squamous cell carcinoma ; Actinic keratosis ; Skin cancer ; Membrane-type matrix metalloproteinase 1 ; Matrix metalloproteinase-2
• 刊名：Pathology - Research and Practice
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：212
• 期：2
• 页码：101-105
• 全文大小：1290 K

文摘

Skin cancer represents the most common worldwide malignancy. Angiogenesis is an important factor in tumor growth and metastasis. Given these facts, the purpose of the current study was to compare the levels of angiogenic proteins in the context of the most common malignant and premalignant skin lesions.

Methods

Immunohistochemistry of CD31, HIF1A, VEGFR1 and VEGFR2 was performed in basal cell carcinoma (BCC), actinic keratosis (AK) and squamous cell carcinoma of the skin (SCCS).

Results

SCCS presented with increased levels of HIF1A, VEGFR1 and VEGFR2 in comparison to AK. In addition, SCCS also demonstrated increased levels of HIF1A to BCCLR or BCCHR. BCC presented with more vessels than AK. However, no correlation was observed among CD31, HIF1A, VEGFR1 and VEGFR2.

Conclusions

SCCS presented with higher levels of HIF1A, VEGFR1 and VEGFR2, while BCC demonstrated an increased number of vessels in relation to AK. These data suggest that antiangiogenic therapy might be useful for skin cancer treatment.