Transforming growth factor ¦Â and apoptosis in leprosy skin lesions: possible relationship with the control of the tissue immune response in the Mycobacterium leprae infection
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- 作者：Juarez Antonio Simoes Quaresma ; Fabr¨ªcio Anderson Carvalho de Almeida ; Tinara Leila de Souza Aarao ; Luis Paulo de Mir ; a Araujo Soares ; Ismaelino Mauro Nunes Magno ; Hellen Thais Fuzii ; Rosana Maria Feio Libonati ; Marilia Brasil Xavier ; Carla Pagliari ; Maria Irma Seixas Duarte
- 关键词：Leprosy ; TGF-¦Â ; Apoptosis ; Cytokines ; Immunopathology ; Mycobacterium leprae
- 刊名：Microbes and Infection
- 出版年：2012
- 出版时间：August, 2012
- 年：2012
- 卷：14
- 期：9
- 页码：696-701
- 全文大小：1118 K
文摘
The course of leprosy depends of the host immune response which ranges from the lepromatous pole (LL) to the tuberculoid pole (TT). A comparative study was conducted in 60 patients with the LL and TT. The results showed a mean expression of TGF-¦Â of 339?¡À?99.4 cells/field for TT and of 519.2?¡À?68.2 cells/field for LL. Frequency of apoptosis was 6.3?¡À?1.8 in TT and 14.0?¡À?6.1 in LL. A correlation (m>p m>?=?0.0251) between TGF-¦Â and caspase-3 in the LL was found. This finding indicates a role of TGF-¦Â and apoptosis in the immune response in leprosy.