Bufadienolides from amphibians: A promising source of anticancer prototypes for radical innovation, apoptosis triggering and Na⁺/K⁺-ATPase inhibition

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• 作者：Lí ; via Queiroz de Sousa^a ; Ká ; tia da Conceiç ; ã ; o Machado^a ; Samara Ferreira de Carvalho Oliveira^b ; Lidiane da Silva Araú ; jo^c ; Evaldo dos Santos Monç ; ã ; o-Filho^c ; Ana Amé ; lia de Carvalho Melo-Cavalcante^a ; Gerardo Magela Vieira-Jú ; nior^c ; Paulo Michel Pinheiro Ferreira^a ; ^d ; ^{pmpf@ufpi.edu.br}
• 关键词：Toad secretion ; Chemical diversity ; Cell death ; Cardiovascular role ; Clinical studies
• 刊名：Toxicon
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：63-76
• 全文大小：2185 K
• 卷排序：127

文摘

Cardenolides and bufadienolides present similar mechanism of Na+/K+-ATPase inhibition. Bufadienolides show moderate selectivity against human tumor cells and weak activity on murine cells. Bufalin, cinobufagin, telocinobufagin and marinobufagin exhibited remarkable antitumor potential triggered by caspase-dependent apoptosis. Bufalin or Cinobufagin have been used in clinical therapy against advanced carcinomas of liver, lung, pancreas and bladder.