Detrimental effect of clomipramine on hippocampus-dependent learning in an animal model of obsessive-compulsive disorder induced by sensitization with d2/d3 agonist quinpirole
详细信息 查看全文
- 作者：Hana Hatalovaa ; 1 ; hana.hatalova@fgu.cas.cz" class="auth_mail" title="E-mail the corresponding author ; Dominika Radostovaa ; 1 ; Adela Pistikovaa ; Karel Valesa ; b ; Ales Stuchlika ; ales.stuchlik@fgu.cas.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：SRIs ; serotonin reuptake inhibitors ; CBT ; cognitive-behavioral therapy ; QNP ; quinpirole ; ACQ ; acquisition session ; REV ; reversal session ; ITI ; inter-trial interval ; CSE ; conditioned stimulus escape ; USE ; unconditioned stimulus escape ; PPX ; pramipexole ; VTA ; ventral tegmental area ; OFC ; orbitofrontal cortex ; DA ; dopamine ; PFC ; prefrontal cortex
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：210-217
- 全文大小：1417 K
文摘
- •
Active place avoidance with reversal is a test of cognitive flexibility.
- •
Quinpirole-sensitized rats in an animal model of OCD display a flexibility deficit.
- •
Clomipramine added to quinpirole causes a severe learning deficit.
- •
Risperidone added to clomipramine and quinpirole rescues performance.