- 作者：Giorgio Danelli ; M. Nuzzi ; P.F. Salcuni ; L. Caberti ; M. Berti ; E. Rossini ; A. Casati ; G. Fanelli
- 关键词：Anesthesia ; Regional ; Carotid endarterectomy ; Superficial cervical plexus block ; Surgery ; Vascular
- 刊名：Journal of Clinical Anesthesia
- 出版年：2006
- 出版时间：December 2006
- 年：2006
- 卷：18
- 期：8
- 页码：585-588
- 全文大小：94 K
To evaluate the effects of adding 50 μg clonidine to 150 mg ropivacaine for superficial cervical plexus block in patients undergoing elective carotid endarterectomy (TEA).
Design
Randomized, double-blind study.
Setting
Departments of Anesthesia and Vascular Surgery of a university hospital.
Patients
40 ASA physical status II and III patients undergoing elective TEA during superficial cervical plexus block.
Interventions
Superficial cervical plexus block was placed using 20 mL of 0.75 % ropivacaine alone (Ropi group, n = 20) or with the addition of 50 μg clonidine (Ropi-Clonidine group, n = 20). If required, analgesic supplementation was given with local infiltration with 1 % lidocaine and intravenous fentanyl (50-μg boluses). Nerve block profile, need for intraoperative analgesic supplementation, and time to first analgesic request were recorded.
Measurements and Main Results
Median (range) onset time was 10 minutes (5-25 min) in the Ropi group and 5 minutes (5-20 min) in the Ropi-Clonidine group (P < 0.05). Intraoperative consumption of both 1 % lidocaine and fentanyl was higher in patients of the Ropi group (15 mL [0-25 mL] and 250 μg [50-300 μg]) than in patients of the Ropi-Clonidine group (8 mL [0-20 mL] and 0 μg [0-150 μg]; P < 0.05 and P < 0.05, respectively). First postoperative analgesic request occurred after 17 hours (10-24 hrs) in the Ropi group and 20 hours (10-24 hrs) in the Ropi-Clonidine group (P > 0.05).
Conclusions
Adding 50 μg clonidine to 150 mg ropivacaine for superficial cervical plexus block shortened the onset time and improved the quality of surgical anesthesia in patients undergoing elective TEA.