Modulation of WNT/β-catenin pathway in melanoma by biologically active components derived from plants

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• 作者：Anna Gajos-Michniewicz ; Malgorzata Czyz ; ^{malgorzata.czyz@umed.lodz.pl" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AKT ; protein kinase B ; APC ; adenomatosis polyposis coli ; ARM ; armadillo ; A375-Ren-Luc ; A375-Renilla-Luciferase ; BCL-9 ; B-cell CLL/lymphoma 9 protein ; BRAF ; serine/threonine-protein kinase B-Raf ; BRG-1 ; Brahma-releted gene 1 ; CAMKII ; calcium/calmodulin-dependent protein kinase II ; cAMP ; cyclic adenosine monophosphate ; CDK ; cycle-dependent kinase ; CCND1 ; gene encoding cyclin D 1 ; CER1 ; cerberus ; CK1α ; casein kinase 1α ; CK1γ ; casein kinase 1γ ; CK1ε ; casein kinase 1ε ; COX-2 ; cyclooxygenase-2 ; CRD-BP
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：109
• 期：Complete
• 页码：283-292
• 全文大小：736 K

文摘

Metastatic melanoma is an aggressive cancer, often resistant to treatment. Therefore, it is essential to determine the molecular mechanisms leading to melanoma or underlying resistance to therapy, and the response to targeted inhibition of the RAS/BRAF/MEK/ERK pathway was a good lesson in this respect. Aberrant WNT/β-catenin pathway is observed in melanoma, and the modulators of this signaling cascade have been under investigation in the context of therapy as well as chemoprevention. Several natural compounds were recognized as being capable of targeting elements of the WNT/β-catenin pathway in various cancers, however, only a few of them can modulate this pathway in melanoma. This review examines recent research on the role of the WNT/β-catenin pathway in tumor development and maintenance, as well as summarizes the current knowledge concerning the modulation of this pathway in melanoma by active compounds of natural origin.