The origins of rimmed vacuoles and granulovacuolar degeneration bodies are associated with the Wnt signaling pathway

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• 作者：Yukari Murata-Shinozaki^a ; Tetsuya Takahashi^a ; ^{tetakaha@hiroshima-u.ac.jp} ; Tomoyasu Matsubara^a ; Hirofumi Maruyama^a ; Yuishin Izumi^b ; Masayasu Matsumoto^a ; ^c
• 关键词：AD ; Alzheimer&rsquo ; s disease ; APC ; adenomatous polyposis coli ; Arf6 ; ADP-ribosylation factor 6 ; CK1δ ; casein kinase 1δ ; Dvl ; dishevelled ; GSK-3β ; glycogen-synthase kinase 3β ; GVD ; granulovacuolar degeneration ; Hsp70 ; heat shock protein 70 ; Lrp4 ; low density lipoprotein-related protein 4 ; PAK1 ; P21-activated kinase 1 ; p-β-catenin ; phospho-β-catenin ; PIP2 ; phosphatidylinositol 4 ; 5-bisphosphate ; PSD95 ; postsynaptic density protein 95 ; RV ; rimmed vacuole ; s-IBM ; sporadic inclusion body myositis
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：638
• 期：Complete
• 页码：55-59
• 全文大小：1909 K
• 卷排序：638

文摘

RVs and GVD bodies share a number of molecules. Wnt signaling might be involved in the formation of RVs and GVD bodies. RV and GVD body formation share common pathogenic mechanisms.