Non-culprit Lesions in Acute Myocardial Infarction: Implications for Multiple Plaque Rupture in Acute Coronary Syndromes
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- 作者：Hugo H. Castañ ; o ; Herman K. Gold ; Tsunehiro Yasuda ; Hiroyuki Matsuura ; Robert D. Dinsmore ; John B. Newell ; Igor F. Palacios ; Erling Falk ; Pedro R. Moreno
- 刊名：Journal of the American College of Cardiology
- 出版年：1995
- 出版时间：February 1995
- 年：1995
- 卷：25
- 期：2, Supplement 1
- 页码：280A
- 全文大小：114 K
文摘
Rupture of atherosclerotic plaques is the most important mechanism underlying acute coronary syndromes. Previous post-mortem studies have shown multiple plaque rupture sites during fatal coronary events. We tested the hypothesis that non-culprit lesions (NCL) decrease in severity after thrombolysis in patients with acute myocardial infarction (AMI). Quantitative coronary angiography was performed before and 9 ± 3 days after rTPA infusion for AMI in 61 consecutive patients (52 males, 9 females, mean age: 53 ± 9 yrs) with 118 NCL mean 1.9 ± 0.9 per patient.
Conclusion: Non-culprit lesions decrease in severity after thrombolysis in acute myocardial infarction suggesting a reversible thrombotic phenomenon probably related to multiple coronary plaque rupture.