Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease
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- 作者：Juan Jose Ramos-Rodrigueza ; Margarita Jimenez-Palomaresb ; Maria Isabel Murillo-Carreteroa ; Carmen Infante-Garciaa ; Esther Berrocosoc ; d ; Fernando Hernandez-Pachoe ; Alfonso Maria Lechuga-Sanchof ; Irene Cozar-Castellanog ; Monica Garcia-Allozaa ; monica.garcia@uca.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：type 2 diabetes ; Alzheimer's disease ; vascular dementia ; amyloid ; phospho-tau ; hemorrhage
- 刊名：Psychoneuroendocrinology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：62
- 期：Complete
- 页码：69-79
- 全文大小：2375 K
文摘
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Central alterations are synergistically worsened in APP/PS1xdb/db mice.
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Early central atrophy, tau pathology and inflammation is detected in APP/PS1xdb/db mice.
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APP/PS1xdb/db mice show a shift in soluble/insoluble Aβ levels towards more toxic soluble species.
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Spontaneous central bleeding synergistically worsened in APP/PS1xdb/db mice.
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Cognition is severely impaired in APP/PS1xdb/db mice in an age dependent manner.