Effects of medial prefrontal cortex lesions on anxiety-like behaviour in restrained and non-restrained rats

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• 作者：Eduardo Blanco ; Estela Castilla-Ortega ; Rubé ; n Mir ; a ; Azucena Begega ; José ; A. Aguirre ; Jorge L. Arias ; Luis J. Santí ; n
• 关键词：Stress ; Frontal cortex ; Elevated T-maze ; Anxiety ; Restraint ; Rodent
• 刊名：Behavioural Brain Research
• 出版年：2009
• 出版时间：12 August 2009
• 年：2009
• 卷：201
• 期：2
• 页码：338-342
• 全文大小：329 K

文摘

The medial prefrontal cortex has been associated with fear, anxiety and stress regulation, and has recently been suggested to play a crucial role in the development of behavioural changes in response to stress. In this study, we evaluated medial prefrontal cortex (mPFC) involvement in both anxiety-like behaviour and increased anxiety-like responses induced by uncontrollable restraint. Rats with mPFC electrolytic lesions (n = 7) and sham-lesioned (n = 8) were tested in the elevated T-maze (ETM). Restrained rats with mPFC lesions (n = 8) and sham-lesioned rats (n = 6) were tested in the elevated T-maze 24 h after restraint. Both two-trial passive avoidance and one-trial escape behaviours were assessed. The results revealed that mPFC lesions impair passive avoidance, but not escape behaviour. In addition, decreased anxiety-like behaviour in both passive avoidance and escape behaviours were observed in restrained rats with mPFC lesions. Our results suggest that mPFC is important in mediating both anxiety-like behaviour expression and long-term anxiogenic-like effects induced by acute restraint.