Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA₁ receptor

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• 作者：Estela Castilla-Ortega ; Jorge Sá ; nchez-Ló ; pez ; Carolina Hoyo-Becerra ; Elisa Matas-Rico ; Emma Zambrana-Infantes ; Jerold Chun ; Fern ; o Rodrí ; guez De Fonseca ; Carmen Pedraza ; Guillermo Estivil
• 关键词：Lysophosphatidic acid ; Knockout mice ; Hole-board ; Principal components factorial analysis ; Spatial reference memory ; Spatial working memory ; Habituation
• 刊名：Neurobiology of Learning and Memory
• 出版年：2010
• 出版时间：July 2010
• 年：2010
• 卷：94
• 期：1
• 页码：73-82
• 全文大小：469 K

文摘

Lysophosphatidic acid (LPA) is a new, intercellular signalling molecule in the brain that has an important role in adult hippocampal plasticity. Mice lacking the LPA₁ receptor exhibit motor, emotional and cognitive alterations. However, the potential relationship among these concomitant impairments was unclear. Wild-type and maLPA₁-null mice were tested on the hole-board for habituation and spatial learning. MaLPA₁-null mice exhibited reduced exploration in a novel context and a defective intersession habituation that also revealed increased anxiety-like behaviour throughout the hole-board testing. In regard to spatial memory, maLPA₁ nulls failed to reach the controls’ performance at the end of the reference memory task. Moreover, their defective working memory on the first training day suggested a delayed acquisition of the task’s working memory rule, which is also a long term memory component. The temporal interval between trials and the task’s difficulty may explain some of the deficits found in these mice. Principal components analysis revealed that alterations found in each behavioural dimension were independent. Therefore, exploratory and emotional impairments did not account for the cognitive deficits that may be attributed to maLPA₁ nulls’ hippocampal malfunction.