Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos
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- 作者：Satoru Tamura ; Gang-Ming Yang ; Natsuko Yasueda ; Yoshiharu Matsuura ; Yasumasa Komoda ; Nobutoshi Murakami
- 关键词：HCV ; Envelope protein E1 ; E2 ; Rosa rugosa Thunb. ; Tellimagrandin I ; Invasion inhibitor
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2010
- 出版时间：1 March 2010
- 年：2010
- 卷：20
- 期：5
- 页码：1598-1600
- 全文大小：332 K
文摘
By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure–activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.