Strawberry tannins inhibit IL-8 secretion in a cell model of gastric inflammation

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• 作者：Marco Fumagalli^a ; Enrico Sangiovanni^a ; Urska Vrhovsek^b ; Stefano Piazza^a ; Elisa Colombo^a ; Mattia Gasperotti^b ; Fulvio Mattivi^b ; Emma De Fabiani^a ; ¹ ; Mario Dell&rsquo ; Agli^a ; ¹ ; ^{mario.dellagli@unimi.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Agrimoniin ; Casuarictin ; Ellagic acid ; Procyanidin B1
• 刊名：Pharmacological Research
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：111
• 期：Complete
• 页码：703-712
• 全文大小：1356 K

文摘

In the present study we chemically profiled tannin-enriched extracts from strawberries and tested their biological properties in a cell model of gastric inflammation. The chemical and biological features of strawberry tannins after in vitro simulated gastric digestion were investigated as well. The anti-inflammatory activities of pure strawberry tannins were assayed to get mechanistic insights.

Tannin-enriched extracts from strawberries inhibit IL-8 secretion in TNFα-treated human gastric epithelial cells by dampening the NF-κB signaling. In vitro simulated gastric digestion slightly affected the chemical composition and the biological properties of strawberry tannins. By using pure compounds, we found that casuarictin may act as a pure NF-κB inhibitor while agrimoniin inhibits IL-8 secretion also acting on other biological targets; in our system procyanidin B1 prevents the TNFα-induced effects without interfering with the NF-κB pathway.

We conclude that strawberry tannins, even after in vitro simulated gastric digestion, exert anti-inflammatory activities at nutritionally relevant concentrations.