Hepatic Microwave Ablation Zone Size: Correlation with Total Energy, Net Energy, and Manufacturer-Provided Chart Predictions

详细信息    查看全文

• 作者：Paul B. Shyn ; MD^a ; ^b ; ^{pshyn@partners.org" class="auth_mail" title="E-mail the corresponding author} ; Jeffery R. Bird ; MD^a ; ^b ; R. Marie Koch ; MD^a ; ^b ; Servet Tatli ; MD^a ; ^b ; Vincent M. Levesque ; MSc^a ; ^b ; Paul J. Catalano ; ScD^c ; Stuart G. Silverman ; MD^a ; ^b
• 关键词：LAD ; long axis diameter ; MW ; microwave ; NE ; net energy ; SAD ; short axis diameter ; TE ; total energy ; V ; volume
• 刊名：Journal of Vascular and Interventional Radiology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：27
• 期：9
• 页码：1389-1396
• 全文大小：1019 K

文摘

To determine whether total energy (TE) reaching the microwave (MW) applicator or net energy (NE) exiting the applicator (after correcting for reflectivity) correlates better with hepatic MW ablation zone dimensions than manufacturer-provided chart predictions.

Materials and Methods

Single-applicator, nonoverlapping ablations of 93 liver tumors (0.7–5.9 cm) were performed in 52 adult patients. TE and NE were recorded for each ablation. Long axis diameter (LAD), short axis diameter (SAD), and volume (V) of each ablation zone were measured on magnetic resonance imaging or computed tomography after the procedure and retrospectively compared with TE; NE; and manufacturer-provided chart predictions of LAD, SAD, and V using correlation and regression analyses.

Results

For treated tumors, mean (± SD) TE and NE were 49.8 kJ (± 22.7) and 36.4 kJ (± 19.4). Mean LAD, SAD, and V were 5.8 cm (± 1.3), 3.7 cm (± 0.8), and 44.1 cm³ (± 25.4). Correlation coefficients (95% confidence interval) with LAD, SAD, and V were 0.46 (0.28, 0.61), 0.52 (0.36, 0.66), and 0.52 (0.36, 0.66) for TE; 0.42 (0.24, 0.58), 0.55 (0.39, 0.68), and 0.53 (0.36, 0.66) for NE; and 0.51 (0.34, 0.65), 0.63 (0.49, 0.74), and 0.60 (0.45, 0.73) for chart predictions. Using regression analysis and controlling for TE, SAD was 0.34 cm larger in patients with cirrhosis than in patients without cirrhosis.

Conclusions

Correcting for reflectivity did not substantially improve correlation of energy values with MW ablation zone size parameters and did not outperform manufacturer-provided chart predictions. Correlations were moderate and variable using all methods. The results suggest a disproportionate influence of tissue factors on MW ablation results.