The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy
详细信息 查看全文
- 作者：Carine Joffre1 ; 5 ; Nicolas Dupont2 ; Lily Hoa3 ; Valenti Gomez3 ; Raul Pardo4 ; Catarina Gonç ; alves-Pimentel4 ; Pauline Achard5 ; Audrey Bettoun1 ; Brigitte Meunier1 ; Chantal Bauvy2 ; Ilaria Cascone1 ; Patrice Codogno2 ; patrice.codogno@inserm.fr" class="auth_mail" title="E-mail the corresponding author ; Manolis Fanto4 ; manolis.fanto@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Alexander Hergovich3 ; a.hergovich@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Jacques Camonis1 ; jacquescamonis@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Biology
- 出版年：2015
- 出版时间：5 October 2015
- 年：2015
- 卷：25
- 期：19
- 页码：2479-2492
- 全文大小：4811 K
文摘
- •
STK38 is a novel binding partner of Beclin1, a key regulator of autophagy
- •
STK38 positively promotes autophagosome formation in human cells and fly larvae
- •
The activation of the STK38 kinase is regulated during the induction of autophagy
- •
STK38 and RalB support the coordination between autophagic and apoptotic events